1846284279_Springer_-_Key.Clinical.Trials.in.Erectile.Dysfunction.Dec.2006(1).pdf

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Key Clinical Trials in
Erectile Dysfunction
Culley C. Carson
Key Clinical Trials in
Erectile Dysfunction
1306791538.002.png
Culley C. Carson, MD, FACS
Rhodes Distinguished Professor
ChiefofUrology
Division of Urologic Surgery
University of North Carolina at Chapel Hill
Chapel Hill, NC, USA
British Library Cataloguing in Publication Data
A catalogue record for this book is available from the British Library
Library of Congress Control Number: 2006923813
ISBN-10: 1-84628-427-9
e-ISBN-10: 1-84628-428-7
ISBN-13: 978-1-84628-427-4
e-ISBN-13: 978-1-84628-428-1
Printed on acid-free paper
© Springer-Verlag London Limited 2007
Apart from any fair dealing for the purposes of research or private study, or criti-
cism or review, as permitted under the Copyright, Designs and Patents Act 1988,
this publication may only be reproduced, stored or transmitted, in any form or by
any means, with the prior permission in writing of the publishers, or in the case
of reprographic reproduction in accordance with the terms of licences issued by
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The use of registered names, trademarks, etc. in this publication does not imply,
even in the absence of a specific statement, that such names are exempt from the
relevant laws and regulations and therefore free for general use.
Product liability: The publisher can give no guarantee for information about drug
dosage and application thereof contained in this book. In every individual case the
respective user must check its accuracy by consulting other pharmaceutical
literature.
987654321
Springer Science
+
Business Media, LLC
Contents
1. The Earliest Carefully Controlled Clinical Trial
Evaluating Oral Pharmacotherapy (Yohimbine)
in ED . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1
1.1 Key Trial References . . . . . . . . . . . . . . . . . . . .
1
1.2 Importance of Study . . . . . . . . . . . . . . . . . . . .
1
1.3 Study Design . . . . . . . . . . . . . . . . . . . . . . . . . .
1
1.4 Key Results . . . . . . . . . . . . . . . . . . . . . . . . . . .
2
1.5 Conclusions from Original Reports . . . . . . . . .
3
1.6 Strengths . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
3
1.7 Weaknesses . . . . . . . . . . . . . . . . . . . . . . . . . . .
3
1.8 Relevance . . . . . . . . . . . . . . . . . . . . . . . . . . . .
3
2. A Description of the Pioneering Work That Led to
the First Approved Agents for ED: Giles Brindley,
the Needle, and the Penis (Phenoxybenzamine) . . . .
4
2.1 Key Trial References . . . . . . . . . . . . . . . . . . . .
4
2.2 Importance of Study . . . . . . . . . . . . . . . . . . . .
4
2.3 Study Design . . . . . . . . . . . . . . . . . . . . . . . . . .
4
2.4 Key Results . . . . . . . . . . . . . . . . . . . . . . . . . . .
5
2.5 Conclusions from Original Reports . . . . . . . . .
6
2.6 Strengths . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
6
2.7 Weaknesses . . . . . . . . . . . . . . . . . . . . . . . . . . .
6
2.8 Relevance . . . . . . . . . . . . . . . . . . . . . . . . . . . .
7
3. The Pivotal Study Showing That Intracorporal
Injection of Vasoactive Agents (Papaverine or
Phenoxybenzamine) Was Effective
Pharmacotherapy . . . . . . . . . . . . . . . . . . . . . . . . . .
8
3.1 Key Trial References . . . . . . . . . . . . . . . . . . . .
8
3.2 Importance of Study . . . . . . . . . . . . . . . . . . . .
8
3.3 Study Design . . . . . . . . . . . . . . . . . . . . . . . . . .
8
3.4 Key Results . . . . . . . . . . . . . . . . . . . . . . . . . . .
9
3.5 Conclusions from Original Reports . . . . . . . . .
10

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